NEUROLOGICAL STATE IN SCHOOL-AGE CHILDREN AFTER TOTAL ANESTHESIA DURING SURGICAL OPERATIONS OF DIFFERENT DURATION

Durdona Zakirova; Yokutxon Madjidova

Authors

Durdona Zakirova PhD candidate, Tashkent Pediatric Medical Institute
Yokutxon Madjidova Doctor of Medical Sciences, Professor, Tashkent Pediatric Medical Institute Tashkent, Uzbekistan

Abstract

This thesis aims to investigate the neurological outcomes in school-age children following surgical procedures performed under total anesthesia, with a focus on comparing the effects of short-duration versus long-duration surgeries. The key objectives are:
To assess the incidence of new-onset neurological deficits, such as motor, sensory, and cognitive impairments, in children after undergoing short-duration (less than 4 hours) versus long-duration (4 hours or more) surgical interventions.

References

Lee, J. H., Park, Y. H., & Kim, J. T. (2018). The effect of anesthesia duration on postoperative cognitive function in children. Anesthesia & Analgesia, 126(5), 1665-1672. https://doi.org/10.1213/ANE.0000000000002780

Satomoto, M., Satoh, Y., Terui, K., Miyoshi, H., Fujimoto, K., Kadoyama, K., & Amagai, T. (2009). Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology, 110(3), 628-637. https://doi.org/10.1097/ALN.0b013e3181974fa2

D. O. (2012). Attention-deficit/hyperactivity disorder after early exposure to procedures requiring general anesthesia. Mayo Clinic Proceedings, 87(2), 120-129. https://doi.org/10.1016/j.mayocp.2011.11.008

Ing, C., DiMaggio, C., Whitehouse, A., Hegarty, M. K., Brady, J., von Ungern-Sternberg, B. S., ... & Sun, L. S. (2012). Long-term differences in language and cognitive function after childhood exposure to anesthesia. Pediatrics, 130(3), e476-e485. https://doi.org/10.1542/peds.2011-3822

Andropoulos, D. B., & Greene, M. F. (2017). Anesthesia and developing brains—Implications of the FDA warning. New England Journal of Medicine, 376(10), 905-907. https://doi.org/10.1056/NEJMp1700196

Stratmann, G. (2011). Review article: Neurotoxicity of anesthetic drugs in the developing brain. Anesthesia & Analgesia, 113(5), 1170-1179. https://doi.org/10.1213/ANE.0b013e318233be69

Vutskits, L., & Xie, Z. (2016). Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nature Reviews Neuroscience, 17(11), 705-717. https://doi.org/10.1038/nrn.2016.128

McCann, M. E., & Soriano, S. G. (2012). General anesthetics in pediatric anesthesia: influences on the developing brain. Current drug targets, 13(7), 944-951. https://doi.org/10.2174/138945012800675404.