ASSESSMENT OF THE DYNAMICS OF HUMORAL IMMUNITY FORMATION WHEN VACCINATION A GROUP OF CHILDREN WITH THE BNT162B2 VACCINE (Pfizer–BioNTech) AGAINST COVID-19 INFECTION
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Abstract
In the research work, the results of taxable samples of mining serum of 205 children in 16 family polyclinics were used. In a retrospective population taxile using epidemiological, serological, statistical methods, the effectiveness of the vaccine against SARS-CoV-2 was evaluated. 7,158 of the 584,181 children living in Tashkent City were vaccinated with 2 doses of the vaccine, 205 children in 16 family polyclinics where the vaccine was carried out were taught karshi IgG to SARS-CoV-2 and anti-cancer (at) belonging to IgM class. The verification process was carried out using a full-fledged automated chemiluminescent immunoanalyzer (medical equipment from Snibe (China)) of the MAGLUMI X3 series in an immunoxemiluminescent taxile (IXLT) method.
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References
On the 21st day after the introduction of the 1st component of the vaccine in the blood of vaccinated children, IgM-At against SARS-CoV-2 was detected in 100% of cases (average value of the positivity coefficient – 4.94), low IgG was anicized in 31.2% of those vaccinated (P=8) (positivity coefficient-24.07);
On the 30th day after vaccination with the 2nd component, however, there was a natural decrease in the amount of IgM against SARS-CoV-2 (the average urine of the positivity coefficient-0.43), the mixer of IgG - at greatly increased and did not change until 30 days (the average value of the positivity coefficient-35.87).
In a portion of those vaccinated (p=32; 71.1% of those observed), an increase in IgG was anicized on the 30th day after vaccination compared to the 14th day.
On the 21st day after vaccination with components 1 and 2, a direct positive correlation bond of 0.69 to 0.29 (r <0.05) was found between the mixor of IgM and IgG