COMPARISON OF THE MANIFESTATION OF OTOTOXICITY OF PLATINUM-BASED CHEMOTHERAPEUTIC AGENTS IN EXPERIMENTAL RESEARCH CONDITIONS

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Published: Aug 13, 2024
Keywords:
cisplatin; carboplatin; ototoxicity; experiment.

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I. B. Bakhadirova
S. S. Arifov
Department of Otorhinolaryngology, Center for the Development of Professional Qualifications of Medical Workers. Tashkent, Uzbekistan.

Abstract

Chemotherapy is one of the main components of treatment of common types of malignant tumors with early metastasis. Platinum-based chemotherapy drugs are widely used in the treatment of malignancies. Representatives of this group of drugs, such as cisplatin and carboplatin, have side effects such as nephrotoxicity, myelosuppression, neurotoxicity and ototoxicity. Ototoxicity is manifested by unilateral or bilateral hearing loss, which may be accompanied by tinnitus. Damage to the hearing organ depends on the dose and cumulative ability of the drug.

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How to Cite
I. B. Bakhadirova, & S. S. Arifov. (2024). COMPARISON OF THE MANIFESTATION OF OTOTOXICITY OF PLATINUM-BASED CHEMOTHERAPEUTIC AGENTS IN EXPERIMENTAL RESEARCH CONDITIONS. Proceedings of International Conference on Modern Science and Scientific Studies, 3(8), 26–28. Retrieved from https://econferenceseries.com/index.php/icmsss/article/view/5430
Issue
Vol. 3 No. 8 (2024): SCMS
Section
Articles
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References

After completion of the 1st course of treatment in the control group, upon otoscopy, the eardrums of all rats were pearly gray in color and pale.