EFFECT OF SUGAR SUBSTITUTE SODIUM CYCLAMATE ON CARBOHYDRATE METABOLISM IN LIVER TISSUE
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Abstract
In this paper, the effect of sodium cyclamate as a artificial sugar substitute, on the amount of glucose and glycogen in the liver tissue of rats was studied under experimental conditions. When sodium cyclamate was administered orally at a dose of 10 mg/kg/day for 60 days, it was observed that the amount of glycogen in the liver tissue of experimental animals decreased. The results indicate the role of sodium cyclamate, a sugar substitute, in the disturbance of carbohydrate metabolism in liver tissue.
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The amount of glycogen accumulated in the liver tissue of healthy experimental animals is almost 2 times more than that of those who consumed sugar substitute products, which indicates that carbohydrate metabolism is normal. It was found that chronically introduced synthetic sodium cyclomate solution affects carbohydrate metabolism in the body and has a negative effect on glycogen formation.