SYNTHESIS OF P-TOLYLPENTACHLOROPHENOXYACETATE AND ITS MOLECULAR DOCKING ANALYSIS

Mamatkulov Nematillo Narzullayevich; Abdushukurov Anvar Kabirovich

Authors

Mamatkulov Nematillo Narzullayevich Associate Professor of the Faculty of Chemistry of the National University of Uzbekistan
Abdushukurov Anvar Kabirovich Professor of the Faculty of Chemistry of the National University of Uzbekistan

Abstract

Substances synthesized on the basis of chloroacetylation reactions of phenol and its derivatives have high biological activity and are widely used in pharmaceuticals as antibacterial, analgesic and bactericidal drugs against pathogenic microorganisms
[1]. Among these are substances such as adrenaline, noradrenaline, isadrin with high biological activity, which are used in medicine as immunostimulants, anti-diabetic and anti-cancer drugs, as well as in pharmaceuticals as hormonal drugs [2,3,4].

References

Рубцов M.B., Байчиков А.Г. Синтеттические химикофармацевтические препараты // Москва: Медицина. -1971. - С. 325.

Абдушукуров А.К., Юлдашев Х.Й. Хлорацетилпирокатехин синтез қилиш усулини такомиллаштириш // Кимё ва фармацевтика. -1993. -№5. -Б. 46-48.

Абдушукуров А.К., Чориев А.У. Пирокотехинни монотетил эфирини хлорацетиллаш ва унинг асосида синтезлар // ЎзРФА маърузалари журнали. - 2013. № 5. -Б. 35-36.

Abdushukurov A.K., Mamatkulov N.N.,Yuldasheva M.R., Rahmonova S. Investigation of o-tolyle ester of chloracetic acid regrouping//April 10-14, Pakistan, Peshavar, -2001. -P. 129.